Missouri to Ohio Road Trip Itinerary
Missouri to Ohio Road Trip Overview
Embark on a varied and enriching road trip from Missouri to Ohio that blends iconic urban landmarks, cultural institutions, and expansive natural landscapes. Begin in St. Louis with time at the Gateway Arch National Park to enjoy skyline views and learn about westward expansion, then wander the tranquil paths and conservatories at the Missouri Botanical Garden. Explore Civil War history at Wilson's Creek National Battlefield and dive into American literature at the Mark Twain Boyhood Home & Museum. Sample local flavor with a stop at Ted Drewes for classic frozen custard and visit the National Frontier Trails Museum to trace pioneer migration routes. Continue east to Kansas City and points beyond, visiting presidential history at the Harry S. Truman Library & Museum and relaxing in Cincinnati's Eden Park and the Krohn Conservatory. Spend family-friendly hours at the Cincinnati Zoo & Botanical Garden before heading into Ohio's cultural heart in Cleveland at the Rock & Roll Hall of Fame. Finish with outdoor adventures at Cuyahoga Valley National Park and the picturesque Hocking Hills State Park for hiking, waterfalls, and scenic vistas. This itinerary suits travelers who enjoy a mix of history, culture, culinary treats, and accessible outdoor recreation, with flexible pacing to add more stops or linger at favorite sites.
Effingham Performance Ctr in Effingham (21.52 mi)
24 Jan 2026
